A Substrate-Independent TR-FRET Histone Deacetylase Inhibitor Assay
نویسندگان
چکیده
منابع مشابه
A substrate-independent TR-FRET histone deacetylase inhibitor assay.
Developing molecularly targeted therapeutics with minimal off-target effects is facilitated by an understanding of compound selectivity. However, for HDAC inhibitors, a clear understanding of specificity has been challenging. In particular, it has been suggested that use of nonspecific substrates and the presence of multiple HDAC activities in enzyme preparations may complicate interpretation o...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2011
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057111422102